Molecular pathway for cancer metastasis to bone Short title: prostate cancer – bone matrix interactions
نویسندگان
چکیده
Grant Acknowledgment: This work was supported by CAPCURE Foundation, NIH DK 60933 to TVB and NIH GM40711 (EHS). ¶ Corresponding author: Tatiana V. Byzova, PhD. Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Departments of Molecular Cardiology, Cardiology and Taussig Cancer Center, Cleveland Clinic Foundation, NB50, 9500 Euclid Avenue, Cleveland, OH 44195. Telephone: 216-445-4312; Fax: 216-445-8204; e-mail: [email protected]
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Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...
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